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PrecivityADTM by C2N was the first AD blood test to get Clinical Laboratory Improvement Amendments protocol certification for use in clinical settings in the United States. The test assesses plasma A-42/40 and the proteotype of apoE. An Amyloid Probability Score, which ranges from 0 to 100 and indicates how probable it is that a person will develop amyloid plaques, is produced by adding age. Low likelihood is represented by a score of zero to 35, moderate by 36 to 57, and high by 58 to 100.
Early clinical studies have shown that combining this p-tau217 Ratio with the amyloid beta 42/40 Ratio of C2N appears to achieve comparable levels of diagnostic performance as the current clinical gold standards of amyloid PET imaging and cerebrospinal fluid tests, including one study in a challenging-to-diagnose real-world population of patients with cognitive impairment or dementia. A key advancement in Alzheimer’s diagnoses is the PrecivityAD2TM blood test. This is especially important since that Alzheimer’s disease-modifying anti-amyloid treatments are under development and might be made accessible to certain patients in the future. Amyloid PET imaging is expensive, still challenging to obtain, and exposes people to radiation, while cerebrospinal fluid biomarkers need a spinal tap. These are just a few of the noteworthy drawbacks of current diagnostic technologies.
The Washington University School of Medicine team, which collaborates with C2N, came up with the conceptual framework for this revolutionary diagnostic tool. It received substantial funding from the GHR Foundation, Alzheimer’s Drug Discovery Foundation, National Institute on Aging, Alzheimer’s Association, and BrightFocus Foundation and was developed and verified by C2N scientists and neurobiologists. Finally, none of these advancements would have been possible without the generosity of several clinical trial volunteers. In the beginning of 2023, our CLIA-certified and CAP-accredited laboratory will introduce the PrecivityAD2TM blood test as a validated laboratory produced test, and C2N looks forward to providing more clinical data and information about it. On Sunday, September 18, JARC held its annual fundraising event, inviting close to 500 individuals to the cutting-edge Pontiac facility of M1 Concourse to support the NGO.
In 45 sites around Metro Detroit, JARC provides assistance to persons with developmental disabilities. These programmes include 24-hour care in group homes, independent living options for adults, and respite care for kids, teenagers, and young adults. The event’s attendees started the evening with a buffet-style supper at several food stations as Class of ’98 performed songs from the 1990s. During dinner, guests got the chance to play Dance Dance Revolution, air hockey, and other arcade games with ’90s themes as well as experience thrilling rides on M1’s Champion Motor Speedway.
After the interior celebrations, visitors were brought to an outdoor tent where they listened to remarks from JARC CEO Shaindle Braunstein and JARC President Joshua Tobias and saw a film presentation on JARC in the 1990s. The main attraction was the band Gin Blossoms.Braunstein said in the event video that “the state supports 80% of our expenditures. Who would choose to live just 80% of a life?
“More has to be done by the international healthcare system to increase the precision of diagnosing people exhibiting cognitive indications or symptoms. According to Oskar Hannson, MD, PhD, senior consultant in neurology at Skne University Hospital in Sweden, full professor of neurology at Lund University, and collaborator with C2N, early misdiagnosis rates are unacceptably high and may be reduced with high-quality diagnostic testing. “I look forward to working with C2N in the coming years to generate the essential data to show that blood-based biomarkers like the PrecivityAD2TM test may make a substantial impact in patients’ lives and enhance how doctors provide treatment,” said the researcher.
“Our current test, the PrecivityAD® blood test, depends on precise measurements of plasma A-42/40 and identification of the Apolipoprotein E proteotype , utilising our unique mass spectrometry technology,” stated Dr. Joel Braunstein, president and CEO of C2N. Our most recent blood test, the PrecivityAD2TM test, is a logical progression from our two years of clinical experience with the PrecivityAD® test. We think that using the PrecivityAD2TM blood test, doctors will typically be able to quickly confirm or exclude the presence of amyloid plaques in their patients with cognitive impairment without the need for further CSF or amyloid PET imaging. This might shorten the time between diagnosis and appropriate therapy for many patients, improve patient accessibility and convenience, and save expenses by doing away with more intricate and expensive amyloid detection procedures.
Do APS ratings assist working doctors in determining if a patient has brain amyloid deposition and, if so, assist them in making a more certain AD diagnosis? C2N conducted research to find out. Before and after PrecivityADTM testing, the business polled 43 memory care professionals from 15 clinics throughout the U.S. on how probable they believed their patient had AD to be. The medical professionals examined 347 patients who were 60 years of age or older and had symptoms of dementia or moderate cognitive impairment. They were 90% Caucasian, with an average age of 74. Among the individuals, 133 had low APS scores, 52 had average scores, and 162 had high APS scores.
The group’s overall likelihood of receiving an AD diagnosis remained the same before and after the test, according to Braunstein. Nevertheless, after reviewing each patient’s specific APS scores, these dementia experts felt more confidence in identifying, or excluding, AD. Prior to testing, doctors claimed to be 58 percent positive of an AD diagnosis in patients who ultimately had low results; this confidence fell to 23 percent after clinicians saw the score. The chance of AD for individuals with intermediate scores decreased modestly, from 64 to 52 percent. AD risk increased from 71 to 89 percent in those with high test scores from pre- to post-test.
| Adam Braunstein Phone Number, Fanmail Address, Email Id and Contact Details | |
|---|---|
| Whatsapp No. | NA |
| https://twitter.com/adambraunstein | |
| Youtube Channel | https://www.youtube.com/channel/UCje9TefN92mvF8dy195H-9w |
| Snapchat | NA |
| Phone Number | (212) 465-6400 |
| Official Website | NA |
| Office Number | NA |
| Office address | NA |
| Linked In | NA |
| https://www.instagram.com/abr8888/ | |
| House address (residence address) | Adam Braunstein Dream Maker Talent Management 43 Glen Cove Road Suite 242 Greenvale, NY 11548 USA |
| https://www.facebook.com/adam.braunstein/ | |
| Email Address | NA |
Adam Braunstein
Dream Maker Talent Management
43 Glen Cove Road
Suite 242
Greenvale, NY 11548
USA
Adam Braunstein Phone Number 2023- This post contains a phone number, house address, Fan mailing address to request autographs, and send fan mail letters to Adam Braunstein. If you want to get an autograph from Adam Braunstein, you can send your handwritten letter to the above address (with a size of 8.5 x 4 inches.) Please wait up to 3 months. If there is no reply, resend your letter or exchange it with another address.
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